This Stem Cell Biology course will provide students with the overview of various types of stem cells, the properties and mechanisms of stem cell renewal, differentiation, as well as reprogramming from somatic cells, de-differentiation and trans-differentiation. Epigenetic mechanisms behind these phenomenons and comparison with early embryo developments and germ cell development will be highlighted. In addition, the application of stem cells in drug screen platform, the applications of stem cells and 3D organoids culture in cell-based therapy and drug screen platform would be covered. The additional value from integrating biomaterials in stem cell research and therapy would also be introduced. The current regulation of cell based therapy in Taiwan and various countries will also be discussed and debated. In addition to taught course and online supplementary teaching material, a selected recent research articles will be introduced and the experimental design behind each original research articles introduced. The students will have the opportunity to gain understanding to the manuscript review process by the "author and reviewer" role playing activities. The scientific oral and written presentation abilities in English will also be developed and accessed.